El famoso detective Sherlock Holmes (Robert Downey Jr.) y su leal compañero, el doctor Watson (Jude Law), se enfrentan ahora a un enemigo inteligente e implacable que podría poner en jaque no sólo a la ciudad de Londres, sino a toda Inglaterra.
Cómic original: Lionel Wigram
Producción ejecutiva: Bruce Berman, Michael Tadross
Producción: Steve Clark-Hall, Susan Downey, Dan Lin, Joel Silver, Lionel Wigram
Fotografía: Philippe Rousselot
Montaje: James Herbert
Casting: Reg Poerscout-Edgerton
Diseño de producción: Sarah Greenwood
Dirección artística: James Foster, Matthew Gray, Niall Moroney
Vestuario: Jenny Beavan
Maquillaje: Christine Blundell, Agnes Legere, Chloe Meddings, Nikita Rae, Clare Ramsey
Departamento artístico: Joseph Alfieri, David Allcock, Ken Burnett, Alison Cardy, Joe Cassar, Netty Chapman, Chris Clarke, Dean Clegg, Liz Colbert, David Conway, Steve Conway, Charlotte Crosbie, Rachel Cutler, Laura Dishington, Gabriela Dolenska, Richard Bryan Douglas, Simon Duric, Hayley Easton, Peter Fentem, Laurent Ferrie, Claire Fleming, Eric Friedewald, Bruce Lee Gross, Alison Harvey, Simon Hutchings, Joseph K. Kepple IV, Dan Kubicek, Eva Kuntz, Charles Leatherland, Pete Lennox, Shay Leonard, Elizabeth Loach, Catriona Maccann, Gary Martin, Stephen McGregor, James McKeown, John Moolenschot, Ian Murray, Craig Narramore, Claire Page, Sandra Phillips, Adrian Platt, Sui Rajakaruna, Stuart Read, Tom Roberts, Matthew Robinson, Ian Rolfe, Bradley Schmidt, Robert Spence, Mike Stallion, Daniel Swingler, Tobias Tomkins, Chris Tooth, Sophie Tyler, Omar Vaid, Bruce Vincent, Lloyd Vincent, Carl Wilson, Dennis Wiseman, Lee Wiseman, Lotta Wolgers, Helen Xenopoulos, Jackie Yau, Mal Zawadzki
Sonido: John Casali, Ishmael Harris, James Mather, Chris Munro, Paul Munro, Luke Neuman
Efectos especiales: James R. Bilz, Jeff Brink, James Davis III, Hugh Goodbody, Mark Holt, Nick Jeffries, Glenn Marsh, Paul McGuinness, Susie O'Sullivan, Chris Reynolds, Charlie Simunik, Mark Vanstone, Mark Weatherbe
Efectos visuales: Dalia Al-Husseini, Daniel Barrow, Howard Berry, Paul Brannan, Isabel Cody, Marcello Da Silva, Graham Day, Hayley Easton, Selcuk Ergen, Pawl Fulker, Mai Gray, Tom Griffiths, Pete Hanson, Oliver Hearsey, Bastian Hopfgarten, Chas Jarrett, Tim Keene, Justin Long, Jason McDonald, Gurel Mehmet, László Molnár, Jonathan Opgenhaffen, Richard Perry, Andy Pinson, Aatesh Shah, Laurence Smith, Sarah Louise Smith, Chris Ung, David Vickery
Casting: Emma Callinan, Meredith Jacobson
Vestuario: Arlynn Abseck, Alison Beard, Sue Bradbear, Anthony Brookman, Rob Brown, Alex Carey, Jenny Hawkins, Helen Ingham, Vivienne Jones, Nathalie Karni, Joe Kowalewski, Charlotte Law, Jane Law, Brian Lawler, Martin Mandeville, Stephen Miles, Steve O'Sullivan, David Otzen, Lora E. Revitt, Clare Spragge, Anabel Temple, Sally Turner, Vanessa Woolgar
Departamento editorial: Sam Daley, Alex Fenn, Philip Hedgecock, Laura Jennings, Richie Roefaro
Departamento musical: Dominic Gibbs
Departamento de transportes: Mark Crowley, Tony Power, Ken Price, Colin Simmons, Gerry Turner
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