En esta segunda entrega del Sherlock Holmes de Guy Ritchie, el detective más famoso de todos los tiempos (encarnado por Robert Downey Jr.) tendrá que hacer frente a los peligrosos planes de su enemigo, el profesor Moriarty (Jared Harris). Holmes contará con la inestimable ayuda del doctor Watson (Jude Law) y lidiará otra vez con una mujer de armas tomar: Irene Adler (Rachel McAdams). Es muy posible que estemos ante la aventura más peligrosa que jamás haya tenido Holmes.
Diseño de personajes: Arthur Conan Doyle
Guión: Kieran Mulroney, Michele Mulroney
Coproducción: Steve Clark-Hall
Producción: Susan Downey, Dan Lin, Joel Silver, Lionel Wigram
Producción ejecutiva: Scott Rudin
Música: Hans Zimmer
Fotografía: Philippe Rousselot
Montaje: James Herbert
Casting: Reg Poerscout-Edgerton
Diseño de producción: Sarah Greenwood
Dirección artística: James Foster, Nick Gottschalk, Matthew Gray, Niall Moroney
Vestuario: Jenny Beavan
Maquillaje: Sylvia Atkins, Michele Barber, Catherine Davies, Annette Field, Patt Foad, Charmaine Fuller, Teri Galati, Liberty Haynes, Davina Lamont, Ailsa Lawson, Laura Lilley, Sarah Jane Marks, Claire Matthews, Laura Milligan, Nina Pratley, Nikita Rae, Adrian Rigby, Karolina Scheepers, Matthew Smith, Nicola Springall, Bunny Stanway-Mayers, Tanya Webb, Helen Conroy, Jesse Rose Rogers
Departamento artístico: Alison Adams, Shurouq Algusane, David Allcock, Will Ayres, Jim Barr, Arthur Beaudoin, Toby Britton, Ken Burnett, Christopher Chandler, Ben Collins, Simon Cook, Will Coubrough, Charlotte Crosbie, Julia Dehoff, Gabriela Dolenska, Jack Dyer, James Enright, Laurent Ferrie, Claire Fleming, Martin Griffiths, Neil Griffiths, Peter Hawkins, Stuart Read, Nicholas Henderson, Simon Hutchings, Eva Kuntz, Shay Leonard, Choi Ho Man, Peter Mann, Tony Marks, Gary Martin, Hugh McClelland, Stephen McGregor, Peter McKinstry, Elly Meyrick, Georgina Millett, Damian Mitchell, John Moolenschot, Steven Morris, Eva Onsrud, Claire Page, Martha Parker, Adrian Platt, Matthew Robinson, Cosmo Sarson, Elliot Scott, Tom Still, Daniel Swingler, Kristin Theyers, Vincent Thomas, Rebecca Todd, Chris Tooth, Remo Tozzi, Thomas Wingrove, Clare Winkworth, Lee Wiseman, Lotta Wolgers, Christopher Wyatt, Rohan Harris, Tom Sinden, Jon Ziman-Bright
Sonido: Dillon Bennett, Jodie Campbell, Steve Finn, James Harrison, Chris Munro, Paul Munro, Becki Ponting, Oliver Tarney, Tristan Tarrant, Rachael Tate, Mark Taylor
Efectos especiales: Charles Adcock, Dean Ford, Michaël Gojon dit Martin, Hugh Goodbody, Mark Holt, Mark Hutchinson, David Johns, Glenn Marsh, Paul McGuinness, Martin 'Marty' McLaughlin, Karl Openshaw
Efectos visuales: Nidhi Agarwal, Lee Alexander, Laya Armian, Adam Azmy, Nithin Babu, Michael Baker, Miles Barry, Angela Barson, Adrian Bell, Mark Beverton, Daniel Booty, Scott Bourne, Stuart Bullen, Jeffrey Burt, Daniel Cairnie, Manjoe Chan, Trevor Chong, Stanley A. Dellimore, Jan Dubberke, Boominathan Frances, Pawl Fulker, Jason Gagnon, Juan Jesus Garcia, Rob Garner, Sarah Gatefield, Mauro Giacomazzo, Erik Gronfeldt, Jan Guilfoyle, Ben Guthrie, Victoria Hodson, Adam Holmes, Bastian Hopfgarten, Chris Hunter, Paul Ingram, Marco Iozzi, Chas Jarrett, Christian Jelen, Mikael Jaeger Jensen, Viv Jim, Christopher Django Johnston, Marc Jones, Paddy Kelly, Arek Komorowski, Sujay Kumar G., Luka Leskovsek, Julian Levi, Justin Long, Natalie Lovatt, Sophie Marfleet, Declan McGuire, Ian Menzies, Mark Millena, Buhas Mohammedunny P., Leona Naidoo, Yoon See Ng, Chris Patrick O'Connell, Conrad Olson, Guo Kun Pan, Oleksandr Panaskevych, Puja Parikh, Steve Parsons, Radhika Patel, Matt Perrin, Richard Perry, Diego Piccinato, Sirio Quintavalle, Michael Ranalletta, Ambrish Rangan, Marc Rice, Mark Richardson, Colin Riley, Philip J. Robinson, Sherri Rogers, Marco Rolandi, Niels Roscher, Sam Salek, B.S. Rajkumar Sapate, Swati Shamsundar Malu, Cameron Sonerson, Susan Stewart, Nigel Stone, Bradey Strong, Alexander Swann, Trevor Tang, Mark Taylor, Mihail Temelkov, Joseph Thomas M., Vincent Thomas, Matthew Tinsley, Jonathan Turner, Vasantharajan.g.d, Damodaran Venkatesan, Mark Webb, Glenn Wells, Blake Winder, James Winnifrith, Anthony Wonsoff, Teh-wei Yeh, Michelle Yu, Chris Zammit
Casting: Emma Callinan, Yannick Karcher
Vestuario: Russell Barnett, Mollie Barr, Dan Blacklock, Frieda Basso Boccabella, Anthony Brookman, Peter k Christopher, François-Louis Delfolie, Ian Foweraker, Mia Gray, Harriet Kendall, Jane Law, Calandra Meredith, Sophie Norinder, Steve O'Sullivan, Jennifer Powell, Kevin Pratten, Lora E. Revitt, Sunita Singh, Nathalie Karni
Departamento editorial: Sam B. Bollinger, Siobhan Boyes, Philip Hedgecock, Todd Kleparski, Angus Munro, Tatjana Rhodes
Departamento musical: Michael Connell, Alejandro de la Llosa, Karen Elliott, Michael Higham, Robert Houston, Steven Kofsky, Andrew Zack
Departamento de transportes: Piotr Chrzanowski, Mark Crowley, Lee Edwards, Darren Fenny, Paul Howitt, Colin Morgan, Chris Morse, Pete Newman, Jérôme Servant, Vincent Servant, Alexandre Thiery, Gerry Turner